Additional file 4: of Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation

Video S4. High-power time-lapse video of axonal mitochondria labeled with TMRM on the day of onset of EAN taken 80 min upon exposing the saphenous nerve. Eighty minutes following the Additional file 3: Video S3, the focal accumulations of functional axonal mitochondria (yellow arrow) appear enlarged in comparison with the earlier time point. Anterograde mitochondrial movement in these axons seems unaffected. Notably, in an axon positioned between the two axons with accumulations (green arrow) and which is of larger diameter than the two indicated with yellow arrows, mitochondrial distribution and morphology appear normal. The video is shown in gray scale in order to improve contrast. (AVI 1353 kb